5-Cyano-2-fluoropyridine

CAS Number 3939-12-6

Fluorinated Building Blocks, Heterocyclic Building Blocks, Materials, Monomers

A fluorinated pyridine building block

Used for the synthesis of APIs and diketopyrrolopyrrole dyes

Overview
Related Products

5-Cyano-2-fluoropyridine (CAS number 3939-12-6) is a pyridine derivative with a fluorine and a nitrile at 2- and 5-positions. An anti-cancer Ube2T inhibitor is synthesised from 5-cyano-2-fluoropyridine through a two-step reaction process. The synthesis begins with the reaction of 5-cyano-2-fluoropyridine and pyrrolidine via nucleophilic aromatic substitution, followed by Pinner reaction to yield the amidine moiety.

5-Cyano-2-fluoropyridine is also employed in the synthesis of pyridine substituted dikeopyrrolopyrroles (DPPs) using diisopropyl succinate. The resulting pyridine-DPPs have bathochromically shifted absorption and emission bands.

Multiple functional groups

For facile synthesis

Fluorinated nicotinonitrile building block

for drug discovery, bioimaging dyes and biochemistry research

Worldwide shipping

Quick and reliable shipping

High purity

>97% High purity

General Information

CAS Number	3939-12-6
Chemical Formula	C₆H₃FN₂
Full Name	5-Cyano-2-fluoropyridine
Molecular Weight	122.10 g/mol
Synonyms	6-Fluoronicotinonitrile, 6-fluoropyridine-3-carbonitrile
Classification / Family	Fluorinated building blocks, Heterocyclic building blocks, APIs, Dyes

Chemical Structure

Product Details

Purity	97%
Melting Point	T_m = 51 °C – 52 °C
Appearance	White crystals

MSDS Documentation

5-Cyano-2-fluoropyridine MSDS Sheet

Literature and Reviews

Discovery of a highly potent and selective dual PROTAC degrader of CDK12 and CDK13, J. Yang et al., J. Med. Chem., 65, 11066–11083(2022); DOI: 10.1021/acs.jmedchem.2c00384.
Mind the metal: a fragment library-derived zinc impurity binds the E2 ubiquitin-conjugating enzyme Ube2T and induces structural rearrangements, J. Med. Chem., 60, 8183–8191(2017); DOI: 10.1021/acs.jmedchem.7b01071.
The impact of the interplay between steric and electronic effects on the synthesis and optical properties of diketopyrrolopyrroles bearing pyridine moieties, O. Vakuliuk et al., ChemPhotoChem, 1, 243–252(2017); DOI: 10.1002/cptc.201600047.
Design, synthesis and antimycobacterial activity of novel nitrobenzamide derivatives, H. Wang et al., Chin. Chem. Lett., 30(2), 413–416(2019); DOI: 10.1016/j.cclet.2018.08.005.

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